1. Reserpine produces profound disruption of conditioned and unconditioned animal behaviour
2. Reserpine reduces the level of catecholamines within the brain
3. About 15% of humans treated with reserpine for hypertension develop depression
4. Thus the depletion in CAs may be related to human depression - this is the CA Theory of Mood
5. The depression produced by reserpine in humans is similar to 'naturally occuring' depression. Thus CA depletion may be responsible for 'naturally occuring' depression.

Use the slider to view the impact of reserpine on transmitter levels in the presynaptic neuron