Effect of Chlorpromazine on Neurotransmitter Release and ReuptakeAuthor Paul Kenyon
|Antipsychotic drugs such
as chlorpromazine are thought to exert their theraputic effects by
blocking DA receptors. Notice that chlorpromazine
attaches to receptor sites in the postsynaptic membrane normally
occupied by dopamine released from the presynaptic neuron.
1. Bridging the information gap between neurones
Neurotransmitters are responsible for transmitting information across the synaptic gap between neurones.
Neurotransmitters are stored in synaptic vesicles. When action potentials are conducted down an axon:
Neurotransmitters in the synaptic cleft :
2. Effect of chlorpromazine
| Point to ponder
Why do you think are the consequences of chronic administration of chlorpromazine on neurotransmitter metabolism?